SUMMIT AGENDA - DAY ONE
9:00 a.m. | Framing the Summit: Welcome and Introduction Richard J. Hodes Ronald A. Kohanski |
Session Chair: Roland Thorpe, Jr., Johns Hopkins Bloomberg School of Public Health | |
9:30 a.m. | Introduction – Health Disparities Frameworks Eliseo J. Pérez-Stable |
10:00 a.m. | Structural Disadvantages and Health Disparities Shannon Zenk |
10:30 a.m. | Health Disparities and Cancers Tiffany Wallace |
11:00 a.m. | Addressing Health Disparities in the Biology of Aging Stacy Carrington Lawrence |
11:30 a.m. | Panel Discussion Jamaine Davis Roland Thorpe, Jr. |
12:00 p.m. | Lunch Break (on your own) |
Session Chair: VJ Periyakoil, Stanford University | |
12:45 p.m. | Centenarians – Exceptional Aging Sofiya Milman |
1:00 p.m. | Aging in Non-Industrialized Contexts: Lessons from Indigenous Populations Michael Gurven |
1:15 p.m. | HIV and Accelerated Aging Kristine Erlandson |
1:30 p.m. | Cancer and Accelerated Aging Mina Sedrak |
1:45 p.m. | ICU Survivors and Accelerated Aging Nathan Brummel |
2:00 p.m. | Panel Discussion Leon McDougle VJ Periyakoil |
2:45 p.m. | Break |
This session will explore the idea that both multimorbidity and geriatric syndromes are emergent properties of underlying global instability intrinsically connected with the biology of aging. Thus, multimorbidity and geriatric syndromes should be considered as fundamental and guiding outcomes when developing a “geroscience toolbox” for geriatricians and their patients. The ideal geroscience toolbox would contain ways to quantify aging and methods to improve health and quality of life for older people. Although most basic research with laboratory animals has focused on specific diseases or individual conditions, the geroscience hypothesis postulates that the biology of aging causes multiple diseases and conditions. Thus, a critical question to be addressed in this session is “How can we use other mammals for geroscience research on multimorbidities and geriatric syndromes?” For basic and translational research, is it helpful to model experimental approaches using naturally occurring multimorbidities in other mammals, or do we need common (overlapping) multimorbidities to advance the geroscience concept beyond single diseases of aging? Session Chair: Alessandro Bartolomucci, University of Minnesota | |
3:15 p.m. | Multimorbidities and Geriatric Syndromes in Humans Luigi Ferrucci |
3:30 p.m. | Multimorbidities and Geriatric Syndromes in Non-Human Primates Ellen Quillen |
3:45 p.m. | Multimorbidities and Geriatric Syndromes in Companion Dogs Natasha Olby |
4:00 p.m. | Morbidities in Diverse Species Caroline Zeiss |
4:15 p.m. | Panel Discussion Noah Snyder-Mackler Alessandro Bartolomucci |
5:00 p.m. | End of Summit Day One |
SUMMIT AGENDA - DAY TWO
9:00 a.m. |
Welcome and Opening Remarks – Summit Day Two Luigi Ferrucci |
Session Chair: Lolita Sai Nidadavolu, Johns Hopkins University |
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9:15 a.m. |
Deficit Accumulation Index Susan Howlett |
9:35 a.m. |
Geriatric Assessment Thomas Gill |
9:55 a.m. |
Frailty and Resilience Jeremy Walston |
10:15 a.m. |
Multisystem/Multilevel Biomarker Associations with Human Aging Eileen Crimmins |
10:35 a.m. |
The Aging Intervention Pipeline Gordon Lithgow |
10:55 a.m. |
Panel Discussion Lolita Sai Nidadavolu |
12:00 p.m. | Lunch Break (on your own) |
Session Chair: Chia-Ling Kuo, Senior Biostatistician, UConn Center on Aging |
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1:00 p.m. |
Modeling Multiple Aspects of Aging Trey Ideker |
1:20 p.m. |
Input Parameters to Model Aging Dan Ehninger |
1:40 p.m. |
Selecting and Extracting Features Relevant to Aging Alex Zhavoronkov |
2:00 p.m. |
Rejuvenation to Model Aging Irina Conboy |
2:20 p.m. |
Panel Discussion Brian Chen Alan Cohen Chia-Ling Kuo |
3:00 p.m. | Break |
Session Chair: Jamie Justice, Assistant Professor, Gerontology and Geriatric Medicine, Wake Forest University |
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3:15 p.m. |
Fundamental Considerations for Biomarkers of Aging Stephen Kritchevsky |
3:30 p.m. |
Biomarkers from the Dunedin Study |
3:45 p.m. |
Organ-specific Biomarkers of Aging Albert Higgins-Chen |
4:00 p.m. |
Bridging Biomarkers of Aging from Model Organisms to Humans Martin Picard |
4:15 p.m. |
Frailty and Epigenetic Biomarkers Alice Kane |
4:30 p.m. |
Panel Discussion Nathan Basisty Jamie Justice Lauren Gaydosh |
5:15 p.m. | End of Summit Day Two |
SUMMIT AGENDA - DAY THREE
9:00 a.m. | Welcome and Opening Remarks – Summit Day Three Ronald A. Kohanski |
Session Chair: Debra Whitman, EVP and Chief Public Policy Officer, AARP
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9:20 a.m. | Geroscience in Prediction Heather Whitson |
9:40 a.m. | Geroscience in Treatment Robert Pignolo |
10:00 a.m. | Geroscience in Management Daniel Forman |
10:20 a.m. | Creating Geroscience-Savvy Clinicians, Patients, and Caregivers George Kuchel |
10:40 a.m. | Panel Discussion Iman Al-Naggar Daniel Parker Erwin Tan |
11:45 a.m. | Lunch Break (on your own) |
SESSION VIII: Geroscience Clinical Trials Session Chair: Jennifer Ailshire, USC
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12:45 p.m. | Translational Geroscience Network: Considerations of Parameters and Populations for Geroscience Clinical Trials James Kirkland |
1:00 p.m. | Primary and Secondary Outcomes of a Geroscience Trial Sara Espinoza |
1:15 p.m. | Geroscience Trial Design for Multimorbidity and Frailty Ilaria Bellantono |
1:30 p.m. | Geroscience Trial Design for Health Disparities Heather Allore |
1:45 p.m. | Panel Discussion Jennifer Ailshire |
2:30 p.m. | Break |
SESSION IX: Looking Forward: Where Do We Go from Here? The goal of this session will be to explore what is needed to form productive new collaborations to advance geroscience. Session facilitators will provide brief summaries of each session along with the key takeaways, and their ideas for next steps to move the field forward. | |
3:00 p.m. | Summaries and Key Takeaways by Session (7 minutes each) Session 1 Facilitator Session 2 Facilitator Session 3 Facilitator Session 4 Facilitator Session 5 Facilitator Session 6 Facilitator Session 7 Facilitator Session 8 Facilitator |
4:00 p.m. | Final Comments and Wrap-Up NIH Director |
4:15 p.m. | Summit Adjourns |