Genetic Modifiers: Lessons from Nervous System Disorders

Description of Workshop

This workshop will bring together a diverse group of researchers with expertise in genetics, genomics, neurology, pathophysiology, and preclinical translation. Understanding genetic factors that modify the onset, progression or severity of diseases can lead to novel therapeutics, facilitate clinical trial design, and enable personalized medicine. The purpose of this workshop is to promote collaborations, confront challenges and highlight successful strategies for genetic modifier discovery, validation, and clinical implementation as part of the NIH Blueprint mission to foster transformative discoveries in neuroscience.

Meeting Dates and Sessions

Day 1 – September 21, 2021 from 10 am – 2 pm EDT
Modifier discovery in human cohorts and model systems, resources available and successful analytical approaches

Day 2 – September 22, 2021 from 10 am – 2 pm EDT
Validation and characterization of modifiers, determining mechanisms of disease modification and mapping modifier pathways

Day 3 – September 23, 2021 from 10 am – 2 pm EDT
Clinical applications of modifiers as therapeutic targets, in design of clinical trials and in precision medicine

Location: ZoomGov virtual meeting. Please register to receive your custom meeting link.

Sponsored By: NIH Blueprint for Neuroscience Research


NIH workshop, co-chaired by:
Susan Ackerman, Ph.D. (University of California, San Diego)

Monica Justice, Ph.D. (The Hospital for Sick Children, University of Toronto)

Marcy MacDonald, Ph.D. (MGH/Harvard University)

Trudy MacKay, Ph.D. (Clemson University)

Huda Zoghbi, M.D. (Baylor College of Medicine)

Stephan Zuchner, M.D., Ph.D. (University of Miami)

NIH Program Staff on Organizing Committee

Inna Belfer, NCCIH

Emily Carifi, NINDS

Valerie Cotton, NICHD

Amelie Gubitz, NINDS

Crystal Lee, NINDS

Roger Little, NIDA

Amy Lossie, NIDA

Daniel Miller, NINDS

Glen Nuckolls, NINDS

Anne Pariser, NCATS

Melissa Parisi, NICHD

Jonathan Pollock, NIDA

Geetha Senthil, NIMH

Maripierre Surpris, NINDS

Contact Us

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