Agenda

Day 1: July 24, 2024
9:00 AM – 4:30 PM

9:00 AM	Welcome and Introduction Douglas Sheeley, ScD Acting Director Office of Strategic Coordination Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI) Office of the Director, NIH
9:15 AM	Keynote Krystal Tsosie, PhD, MPH, MA Assistant Professor in the School of Life Sciences at Arizona State University Associate Director of the Biodiversity Knowledge Integration Center at ASU
10:00 AM	NIH Common Fund/CFDE Resources George Papanicolaou, PhD Common Fund Data Ecosystem (CFDE) Program Leader Office of Strategic Coordination Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI) Office of the Director, NIH
10:30 AM	Break
10:45 AM	Panel Discussion on How Data Policy (Privacy and Ethics) Impacts Historically Underserved Communities Panelists: • Mitchell Lunn, MD, MAS, FACP, FASN Associate Professor of Medicine (Nephrology) and of Epidemiology and Population Health at Stanford University School of Medicine • Nyasha Chambwe, PhD Assistant Professor, Institute of Molecular Medicine, Feinstein Institutes for Medical Research • Krystal Tsosie, PhD, MPH, MA Assistant Professor in the School of Life Sciences at Arizona State University Associate Director of the Biodiversity Knowledge Integration Center at ASU Moderator: TBD
12:00 PM	Lunch
1:00 PM	Workshop Breakout Session on Community Engagement Strategies These will be interactive sessions where attendees will have the opportunity to break out into small groups to address a series of questions. Virtual attendees will be able to participate in the discussion in virtual break out rooms. Moderators: • Desiree Shantai Smith, MPH, DrPh Health Equity Research and Evaluation • Karriem Watson, DHSc., MS, MPH Chief Engagement Officer, NIH All of Us Research Program • Erin Beck, MS Biomedical Informatics Project Manager National Cancer Institute (NCI), NIH
2:00 PM	Panel Discussion on Data Use and Accessibility Panelists: • Frank Elavsky Research Assistant, Human Computer Interaction Institute, Carnegie Mellon University • Seth Berke Research Assistant position at the Johns Hopkins Bloomberg School of Public Health • Katherine Kim, PhD, MPH, MBA, FAMIA Adjunct Full Professor at University of California Davis, School of Medicine, Department of Public Health Sciences Senior Scientist for Health at CITRIS (Center for Information Technology Research in the Interest of Society) at UC Berkeley Moderator: Maryam Zaringhalam, PhD Data Science and Open Science Officer in the National Library of Medicine’s Office of Strategic Initiatives, NIH
3:00 PM	Break
3:15 PM	Workshop Breakout Session on Data Challenges and Barriers to Data Use These will be interactive sessions where attendees will have the opportunity to break out into small groups to address a series of questions. Virtual attendees will be able to participate in the discussion in virtual break out rooms. Moderators: • Lauren Amos, PhD Deputy Area Director for State and Local Human Services, Mathematica • Samson Gebreab, PhD, MSc Program Lead, AIM-AHEAD Office of Data Science Strategy (ODSS) Office of the Director, NIH • Avi Ma’ayan, PhD Mount Sinai Endowed Professor in Bioinformatics Professor, Department of Pharmacological Sciences Director, Mount Sinai Center for Bioinformatics
4:15 PM	Closing Remarks
4:30 PM	Adjourn Day 1

Welcome and Opening Remarks
9:00 AM	NINDS Welcome Walter J. Koroshetz, MD Director, National Institute of Neurological Disorders and Stroke
9:10 AM	Engaging the Lived Experience Perspective on PD Therapeutics Rebekah Corlew, PhD Lived Experience Engagement Strategist, National Institute of Neurological Disorders and Stroke
Keynote Address: Landscape of PD Therapeutics Development
9:20 AM	Workshop Co-Chairs Welcome and Goals for the 2 Days Alice Chen-Plotkin, MD Parker Family Professor of Neurology, University of Pennsylvania Bill Martin, PhD Global Neuroscience Therapeutic Area Head, Johnson & Johnson Innovative Medicine
10:00 AM	Break (5 minutes)
Session 1: PD Heterogeneity Moderator: Karl Kieburtz, MD, MPH, Professor, University of Rochester
10:05 AM	Motor Heterogeneity in Parkinson’s Disease: Challenges to Therapeutic Developments Anthony Lang, MD, FRCPC Director, Edmond J Safra Program in Parkinson’s Disease, University of Toronto
10:20 AM	Heterogeneity of Non-Motor Symptoms across Lewy Body Diseases Kathleen Poston, MD, MS, Edward F. and Irene Thiele Pimley Professor in Neurology and Neurological Sciences, Director, Stanford Movement Disorders Center, Stanford University
10:35 AM	Q & A Discussion (30 minutes)
11:05 AM	Break (10 minutes)
Session 2: Target Validation Moderator: Alice Chen-Plotkin, MD, Parker Family Professor of Neurology, University of Pennsylvania
11:15 AM	Evolving Arcs toward Disease-Modifying Therapy for Parkinson’s Michael Schwarzschild, MD, PhD Professor of Neurology, Massachusetts General Hospital, Harvard Medical School
11:30 AM	Targeting LRRK2: Why, Who, Where and When Mark R. Cookson, PhD National Institute on Aging
11:45 AM	An Industry Perspective on Target Validation For Neurologic Diseases David Stone, PhD VP, Head of Genetics and Target Identification, Cerevel Therapeutics, LLC
12:00 PM	Q & A Discussion (30 minutes)
12:30 PM	Lunch (60 minutes)
Session 3: Appropriate Tools to Enable Therapeutics Development Moderator: Shalini Padmanabhan, PhD, Vice President, Discovery & Translational Research, Michael J. Fox Foundation
1:30 PM	Teeing Up a Discussion about Appropriate Tools to Enable Therapeutics Development Patrik Brundin, MD, PhD Distinguished Scientist/Therapeutic Area Leader for Movement Disorders, Roche
1:45 PM	Preclinical Tools to Advance Parkinson Disease Therapeutics: What They Can and Cannot Do Laura Volpicelli-Daley, PhD Associate Professor, University of Alabama at Birmingham
2:00 PM	Q & A Discussion (30 minutes)
2:30 PM	Break (10 minutes)
Session 4: Biomarker Use Moderator: Danielle Graham, PhD, Head of Fluid Biomarkers and Bioanalysis, Biogen
2:40 PM	AI-Enabled Biomarkers: A Window into Parkinson’s Progression, Detection, and Treatment Response Dina Katabi, PhD Thuan and Nicole Pham Professor, Massachusetts Institute of Technology
2:55 PM	Identification of Proteomic Targets and Biomarkers: The Mapping Proteomics to Parkinson’s Disease Project (MAP2PD) Laura Winchester, DPhil Research Fellow, University of Oxford
3:10 PM	Understanding Biomarker Parameters to Enable Clinical Trials in Parkinson’s Disease Danielle Graham, PhD Head of Fluid Biomarkers and Bioanalysis, Biogen
3:25 PM	Q & A Discussion (30 minutes)
3:55 PM	Break (15 minutes)
Breakout Session Day 1
4:10 PM	Parallel Breakout Session What is missing that is holding back therapeutics development?
4:55 PM	Break (5 minutes)
End of Day 1
5:00 PM	Day 1 Wrap-up
5:10 PM	Adjourn for the day

Day 2: July 25, 2024
9:00 AM – 12:30 PM

9:00 AM	Panel Discussion on Training & Education Needs of the Data Community *Panelists:* • Jenea Adams, MS Penn Presidential Ph.D. Fellow and Ph.D. candidate in Genomics and Computational Biology Founder and Executive Director of the Black Women in Computational Biology Network (BWCB) • Kevin Cassel, DrPH, MPH Associate Director, Community Outreach and Engagement Office Associate Professor Population Sciences in the Pacific Program University of Hawaii Cancer Center • Zaki Sherif, PhD Tenured Full Professor at Howard University College of Medicine and an Adjunct Professor at Georgetown University School of Medicine Moderator: Nandita Rahman Director of Data Governance, Office of Data and Analytics, All of Us Research Program
10:00 AM	Two Concurrent Breakout Sessions These will be interactive sessions where attendees will have the opportunity to break out into small groups to address a series of questions. Virtual attendees will be able to participate in the discussion in virtual break out rooms. a. Workshop Breakout on Data Solutions to identified barriers from Day 1 Moderators: • Lauren Amos, PhD Deputy Area Director for State and Local Human Services, Mathematica • Samson Gebreab, PhD, MSc Program Lead, AIM-AHEAD Office of Data Science Strategy (ODSS) Office of the Director, NIH • Avi Ma’ayan, PhD Mount Sinai Endowed Professor in Bioinformatics Professor, Department of Pharmacological Sciences Director, Mount Sinai Center for Bioinformatics b. Workshop Breakout to discuss the immediate Training Needs and Supports of the Community Moderators: • Rachel Britt, PhD Strategic Planning, Evaluation, and Communications Team Leader Office of Strategic Coordination, The Common Fund Division of Program Coordination, Planning, and Strategic Initiatives Office of the Director, NIH • MacKenzie Brandes, MBA Project Manager I, Metabolism Program, Diabetes Broad Institute • Noël Burtt Director, Operations & Development, Diabetes Research & Knowledge Portals Program in Medical and Population Genetics Broad Institute of Harvard and MIT
11:20 AM	Break
11:30 AM	Workshop Closing Presentation & Wrap Up Chris Kinsinger, PhD Assistant Director for Catalytic Data Resources Office of Strategic Coordination Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI) Office of the Director, NIH
12:30 PM	Adjourn Day 2

Agenda

Day 1: July 24, 20249:00 AM – 4:30 PM

Day 2: July 25, 20249:00 AM – 12:30 PM

Day 1: July 24, 2024
9:00 AM – 4:30 PM

Day 2: July 25, 2024
9:00 AM – 12:30 PM