75th Anniversary Trainee Symposium: Celebrating NIDCR Trainees: Past, Present, and Future

Alejandro (Alex) Chibly

Bioinformatics Scientist in Reverse Translation (Oncology signaling) and Oncology Bioinformatics. My main areas of focus include hormone receptor-positive breast and prostate cancer biology, as well as mechanisms of response and resistance to endocrine therapy, CDK4/6i and PI3Ki. I specialize in the analysis of transcriptomic and genomic data from patient-derived tumors using regression and machine learning tools to identify actionable targets for potential use in combination therapies, and to understand mechanisms of inherent and acquired resistance to cancer therapies. I got a PhD in Cancer Biology from the University of Arizona in the laboratory of Dr. Kirsten Limesand, and did a post-doc training at the National Institute of Dental and Craniofacial Research (NIDCR/NIH) with Dr. Matt Hoffman. My previous research focused on investigating molecular mechanisms associated with salivary gland dysfunction that occurs as a consequence of cancer radiotherapy, where I led the generation of a single-cell RNAseq atlas of salivary gland development, and the transcriptional profiling of human irradiated salivary glands to identify clinically relevant targets to develop curative strategies for loss of saliva.