Agenda
Wednesday, March 4
1:00-3:00 PM: Science Talks Session 1
3:00-3:20 PM: Break
3:20-5:00 PM: Science Talks Session 2
5:00 PM: Adjournment
5:30-6:30 PM: Happy Hour at The Bethesdan Hotel
Thursday, March 5
9:00-10:30 AM: Science Talks Session 3
10:30-10:45 AM: Break
10:45-11:45 AM: Poster Session A
11:45 AM-1:00 PM: Lunch (on your own)
1:00-2:00 PM: Poster Session B
2:00-3:20 PM: Science Talks Session 4
3:20-3:40 PM: Break
3:40-5:00 PM: Science Talks Session 5
5:00 PM: Adjournment
Friday, March 6
9:00-10:20 AM: Science Talks Session 6
10:20-10:35 AM: Break
10:35 AM-12:00 PM: Science Talks Session 7
12:00 PM: Adjournment
Wednesday, March 4
| 1:00 – 1:05 PM | Welcome | |
| 1:05 – 1:20 PM | NIH Director | |
| Session 1 | Moderator: Trish Labosky | |
| 1:20 – 1:40 PM | A New Strategy to Advance CAR T Cell Therapy for Solid Tumors: Unlocking the Therapeutic Window Through Tumor Irradiation Early Independence Award, 2021 |
Jalal Ahmed Icahn School of Medicine at Mount Sinai |
| 1:40 – 2:00 PM | The Promise of Precision in Somatic Cell Genome Editing In Vivo New Innovator Award, 2019 |
Alexandros Poulopoulos University of Maryland School of Medicine |
| 2:00 – 2:20 PM | Defining the Lasting Transcriptomic, Epigenetic, and Proteomic Signatures of Memory New Innovator Award, 2021 |
Erica Korb University of Pennsylvania |
| 2:20 – 2:40 PM | Alzheimer’s Disease is Caused by Dysregulation of Innate Immunity by Unperceived, Undiagnosed, and Untreated Polymicrobial Co-Infections—And Can Be Prevented Pioneer Award, 2020 |
Annelise Barron Stanford University, School of Medicine |
| 2:40 – 3:00 PM | Bioelectronic Contrast Agents (BECAs) for Functional Magnetic Resonance Imaging of Neurophysiology New Innovator Award, 2020 |
Aviad Hai University of Wisconsin Madison |
| 3:00 – 3:20 PM | Break | |
| Session 2 | Moderator: Wen Chen | |
| 3:20 – 3:40 PM | Spatial Patterning of the Epigenome During Early Embryonic Development New Innovator Award, 2019 |
Marcos Simoes-Costa Harvard University |
| 3:40 – 4:00 PM | Protein Folding Success Depends on the Direction and Speed of Polypeptide Chain Appearance Pioneer Award, 2021 |
Patricia Clark University of Notre Dame |
| 4:00 – 4:20 PM | Instructive Influence of Motor Cortex on Muscle Activity During Ethological Motor Behavior New Innovator Award, 2020 |
Andrew Miri Northwestern University |
| 4:20 – 4:40 PM | Nucleosome Stability Safeguards Cell Identity, Stress Resilience and Healthy Aging Transformative Research Award, 2020 |
Peter Adams Sanford Burnham Prebys Medical Discovery Institute |
| 4:40 – 5:00 PM | Hypoglycemia In Motor-Neurons Impairs Nuclear Import and Leads to ALS Molecular Pathology Transformative Research Award, 2021 |
Liam Holt NYU School of Medicine |
| 5:30 – 6:30 PM | Happy Hour at Fialova, located in the lobby of The Bethesdan Hotel |
Thursday, March 5
| 9:00 – 9:10 AM | Program Remarks | |
| Session 3 | Moderator: Ananda Roy | |
| 9:10 – 9:30 AM | Ghost in the Machine: An Implantable Device that Converses with Patients and Learns to Co-Manage Epilepsy Pioneer Award, 2020 |
Brian Litt University of Pennsylvania |
| 9:30 – 9:50 AM | Leveraging Evolutionary-Scale Enzymology to Map and Predict Catalytic Landscapes Early Independence Award, 2022 |
Margaux Pinney University of California, Berkeley |
| 9:50 – 10:10 AM | Maternal-Fetal Immune Conflict in a Mouse Model of Neurodevelopmental Disorders New Innovator Award, 2022 |
Lucas Cheadle Cold Spring Harbor Laboratory/Howard Hughes Medical Institute |
| 10:10 – 10:30 AM | Fusion of Nanomagnetic and Viral Tools to Interrogate Brain-Body Circuits Pioneer Award, 2021 |
Polina Anikeeva Massachusetts Institute of Technology |
| 10:30 – 10:45 AM | Break | |
| 10:45 – 11:45 AM | Poster Session 1 | |
| 11:45 AM – 1:00 PM | Lunch | |
| 1:00 – 2:00 PM | Poster Session 2 | |
| Session 4 | Moderator: Pam Birriel | |
| 2:00 – 2:20 PM | Landscape and Mechanisms of Transposon-Associated Alternative Splicing New Innovator Award, 2020 |
Alice Eunjung Lee Boston Children’s Hospital / Harvard Medical School |
| 2:20 – 2:40 PM | The DAMPRs: Human DNA Damage-Ameliorating Proteins for Slowing Age-Related Diseases Pioneer Award, 2020 |
Susan Rosenberg Baylor College of Medicine |
| 2:40 – 3:00 PM | Protein Folding in the AI Era: What’s Left to Discover? New Innovator Award, 2020 |
Stephen Fried Johns Hopkins University |
| 3:00 – 3:20 PM | The Non-Genetic Non-Environmental Origins of the Missing 50% of Disease Risk Transformative Research Award, 2021 |
Joseph Nadeau, Maine Medical Center Andrew Pospisilik, Van Andel Institute |
| 3:20 – 3:40 PM | Break | |
| Session 5 | Moderator: Becky Miller | |
| 3:40 – 4:00 PM | Lipid Nanoparticle-Based Delivery of CRISPR/Cas9 Machinery Enables Site-Specific Integration of CFTR and Mutation-Agnostic Disease Rescue Early Independence Award, 2019 |
Steven Jonas University of California, Los Angeles |
| 4:00 – 4:20 PM | Using Zebrafish to Study Neurodevelopmental Disorders and Discover Treatments New Innovator Award, 2022 |
Summer Thyme UMass Chan Medical School |
| 4:20 – 4:40 PM | Precision Editing of Brain Circuits Using an Engineered Electrical Synapse Pioneer Award, 2022 |
Kafui Dzirasa Duke/Howard Hughes Medical Institute |
| 4:40 – 5:00 PM | Metabolic Pathway in the Nucleus Controls Epigenetic Plasticity New Innovator Award, 2020 |
Subhamoy Dasgupta Roswell Park Comprehensive Cancer Center |
Friday, March 6
| Session 6 | Moderator: Kaitlyn Browning | |
| 9:00 – 9:20 AM | CRISPR-Hybrid: An Intracellular Directed Evolution Platform for Functional RNA Aptamers in Multiplexed Gene Regulation New Innovator Award, 2019 |
Jia Niu Boston College |
| 9:20 – 9:40 AM | Discovery of Functional Chimeric mRNA Encoded Proteins in Mammalian Immunity New Innovator Award, 2021 |
Ruaidhrí Jackson Harvard Medical School, Immunology Department |
| 9:40 – 10:00 AM | Discovery of a Hidden DNA Element That Helps Switch On Genes from Afar New Innovator Award, 2022 |
Evgeny Kvon University of California, Irvine |
| 10:00 – 10:20 AM | Cross Kingdom Health: Evolutionary Innovations in Innate Immunity New Innovator Award, 2021 |
Ksenia Krasileva University of California, Berkeley |
| 10:20 – 10:35 AM | Break | |
| Session 7 | Moderator: Richard Conroy | |
| 10:35 – 10:55 AM | Optogenetic RNA Relocalization Reveals Causal Pathological Drivers of Neural Function In Vivo Pioneer Award, 2023 |
Lei Stanley Qi Stanford University |
| 10:55 – 11:15 AM | Small Molecule Homeostatic Modulation of Neurodegenerative Diseases Transformative Research Award, 2021 |
Qun Lu University of South Carolina |
| 11:15 – 11:35 AM | Structural Basis for Regulation of Frizzled-4 Signaling by the Co-Receptor Tetraspanin-12 Early Independence Award, 2023 |
Katherine Susa University of California, San Francisco |
| 11:35 – 11:55 AM | Vascular Signaling Plasticity Reprograms Brain Hemodynamics to Optimize Learning New Innovator Award, 2020 |
Thomas Longden University of Maryland Baltimore |
| 11:55 AM – 12:00 PM | Closing Remarks |